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An experimental model for pharmacokinetic studies of monoclonal antibodies in human colonic cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
1987 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 26, no 6, 447-451 p.Article in journal (Refereed) Published
Abstract [en]

An experimental model consisting of athymic rats carrying human colonic tumours from cell line LS 174T in both hind legs was used. 125I-labelled anti-carcinoembryonic antigen (anti-CEA) monoclonal antibodies were injected intra-arterially (i.a.), either alone (21 rats) or together with degradable starch microspheres (6 rats). As a control, an irrelevant antibody was injected i.a., alone (6 rats) or together with microspheres (3 rats). An intra-arterial injection was given on the side bearing one tumour in each rat, while the contralateral tumour served as an 'intravenous' control. The rats were submitted to external gamma measurements daily for four days. On the fourth day they were killed and pieces from the tumours and from various organs were examined by in vitro measurements. The results indicate strong expression of CEA in LS 174T cells grafted to athymic rats. No lasting enhancement of the tumour uptake was achieved by intra-arterial injection of antibodies as compared with the control tumours.

Place, publisher, year, edition, pages
1987. Vol. 26, no 6, 447-451 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-149090PubMedID: 3155399OAI: oai:DiVA.org:uu-149090DiVA: diva2:403957
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2017-12-11Bibliographically approved

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