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Localization of prostanoid receptors in the mouse inner ear
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2011 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 131, no 2, 142-148 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: EP4, EP2, and IP prostanoid receptors exert an otoprotective function and FP may be important for fluid homeostasis in the inner ear. Objective: To investigate the expression of prostanoid receptors in the normal mouse inner ear. Methods: CBA/J mice were used in this study. The localization of prostanoid receptors, i.e. DP, EP1, EP2, EP3, EP4, FP, IP, and TP, in the inner ear, i.e. the cochlea, vestibular end organs, endolymphatic sac, was studied by immunohistochemical techniques. Results: The EP4, IF, and FP prostanoid receptors were found to be abundantly distributed in many inner ear structures, i.e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, and the endolymphatic sac. EP2 and EP3 are also localized in the inner ear whereas DP, EP1, and TP are only weakly expressed.

Place, publisher, year, edition, pages
2011. Vol. 131, no 2, 142-148 p.
Keyword [en]
Immunohistochemistry, otoprotection, fluid homeostasis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-149085DOI: 10.3109/00016489.2010.524939ISI: 000286647900005PubMedID: 21062117OAI: oai:DiVA.org:uu-149085DiVA: diva2:403987
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2017-12-11Bibliographically approved

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Anniko, Matti

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