uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Localization of prostanoid receptors in the mouse inner ear
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2011 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 131, no 2, 142-148 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: EP4, EP2, and IP prostanoid receptors exert an otoprotective function and FP may be important for fluid homeostasis in the inner ear. Objective: To investigate the expression of prostanoid receptors in the normal mouse inner ear. Methods: CBA/J mice were used in this study. The localization of prostanoid receptors, i.e. DP, EP1, EP2, EP3, EP4, FP, IP, and TP, in the inner ear, i.e. the cochlea, vestibular end organs, endolymphatic sac, was studied by immunohistochemical techniques. Results: The EP4, IF, and FP prostanoid receptors were found to be abundantly distributed in many inner ear structures, i.e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, and the endolymphatic sac. EP2 and EP3 are also localized in the inner ear whereas DP, EP1, and TP are only weakly expressed.

Place, publisher, year, edition, pages
2011. Vol. 131, no 2, 142-148 p.
Keyword [en]
Immunohistochemistry, otoprotection, fluid homeostasis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-149085DOI: 10.3109/00016489.2010.524939ISI: 000286647900005PubMedID: 21062117OAI: oai:DiVA.org:uu-149085DiVA: diva2:403987
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2015-02-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Anniko, Matti
By organisation
Otolaryngology and Head and Neck Surgery
In the same journal
Acta Oto-Laryngologica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 123 hits
ReferencesLink to record
Permanent link

Direct link