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Alterations in Cerebrospinal Fluid PO2, PCO2, and pH Measurements during and after Experimental Thoracic Aortic Cross-Clamping
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
2009 (English)In: Annals of Vascular Surgery, ISSN 0890-5096, E-ISSN 1615-5947, Vol. 23, no 1, 122-127 p.Article in journal (Refereed) Published
Abstract [en]

In a model of aortic cross-clamping, we studied the use of a multiparameter sensor for measurement of cerebrospinal. fluid (CSF) PO2, PCO2, and pH during and after aortic cross-clamping. The present study addressed the above-mentioned alterations and their relation according to time intervals. In 31 pigs, a sensor was introduced into the intrathecal space and epidural laser Doppler was used to measure spinal cord blood. flow (SCF). By placing the aortic clamp at different levels, three different spinal cord ischemia groups were obtained (mild, moderate, and severe). CSF variables with SCF were studied for 25%, 50%, and 100% changes according to baseline level. In the clamping period, SCF decreased 71.5%, 40.0%, and 33.3% in groups 1, 2, and 3, respectively. CSF O-2 tension reached 0 in group 1, decreased 74.8% in group 2, and was 12.7% in group 3. CSF CO2 tension increased 247.2% and 202.0% in groups 1 and 2, respectively, but slightly increased in group 3. The maximum reaction time of CSF O-2 tension was about 16.7-26.9 min, although this range was 34.5-49.8 min in CSF CO2 tension. We recognized that O-2 tension reacts faster than PCO2 and pH. It is possible for O-2 tension to be used faster than produced CO2 in the ischemic medium, although it is known that the diffusion rate of CO2 is much higher. Spinal cord O-2 tension monitoring is an important method to detect ischemic changes.

Place, publisher, year, edition, pages
2009. Vol. 23, no 1, 122-127 p.
National Category
URN: urn:nbn:se:uu:diva-149163DOI: 10.1016/j.avsg.2008.06.004ISI: 000262328800019OAI: oai:DiVA.org:uu-149163DiVA: diva2:404059
Available from: 2011-03-15 Created: 2011-03-15 Last updated: 2011-03-15Bibliographically approved

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