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Response to temozolomide and bevacizumab in a patient with poorly differentiated neuroendocrine carcinoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Endokrin tumörbiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Endokrin tumörbiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi)
2012 (English)In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 29, no 1, 301-303 p.Article in journal (Refereed) Published
Abstract [en]

Poorly differentiated endocrine carcinomas (PDEC) are usually treated with cisplatin-based chemotherapy regimens. We here present a case with a dramatic response (both radiologically and biochemically) to the combination of temozolomide and bevacizumab, after failure of cisplatin and etoposide, with continued tumor shrinkage at 5 months. Temozolomide combined with bevacizumab might be a good treatment option in PDEC, perhaps even in a first-line setting. Prospective studies to answer this are warranted.

Place, publisher, year, edition, pages
2012. Vol. 29, no 1, 301-303 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-149251DOI: 10.1007/s12032-010-9789-4ISI: 000300317200046PubMedID: 21191667OAI: oai:DiVA.org:uu-149251DiVA: diva2:404245
Available from: 2011-03-16 Created: 2011-03-16 Last updated: 2017-12-11Bibliographically approved

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Lindholm, Daniel PEriksson, BarbroGranberg, Dan

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