Synthetic geopolymers for controlled delivery of oxycodone: Adjustable and nanostructured porosity enables tunable and sustained drug release
2011 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 6, no 3, e17759- p.Article in journal (Refereed) Published
In this article we for the first time present a fully synthetic mesoporous geopolymer drug carrier for controlled release of opioids. Nanoparticulate precursor powders with different Al/Si-ratios were synthesized by a sol-gel route and used in the preparation of different geopolymers, which could be structurally tailored by adjusting the Al/Si-ratio and the curing temperatures. In particular, it was shown that the pore sizes of the geopolymers decreased with increasing Al/Si ratio and that completely mesoporous geopolymers could be produced from precursor particles with the Al/Si ratio 2:1. The mesoporosity was shown to be associated with a sustained and linear in vitro release profile of the opioid oxycodone. A clinically relevant release period of about 12 h was obtained by adjusting the size of the pellets. The easily fabricated and tunable geopolymers presented in this study constitute a novel approach in the development of controlled release formulations, not only for opioids, but whenever the clinical indication is best treated with a constant supply of drugs and when the mechanical stability of the delivery vehicle is crucial.
Place, publisher, year, edition, pages
2011. Vol. 6, no 3, e17759- p.
Engineering and Technology
Research subject Engineering Science with specialization in Materials Science; Engineering Science with specialization in Nanotechnology and Functional Materials
IdentifiersURN: urn:nbn:se:uu:diva-149263DOI: 10.1371/journal.pone.0017759ISI: 000288513900022OAI: oai:DiVA.org:uu-149263DiVA: diva2:404358