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Well-Tolerated Chemoprophylaxis Uniformly Prevented Swedish Soldiers from Plasmodium falciparum Malaria in Liberia, 2004-2006
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centrum för klinisk forskning i D län (CKFD).
2008 (English)In: Military medicine, ISSN 0026-4075, Vol. 173, no 12, 1194-1198 p.Article in journal (Refereed) Published
Abstract [en]

Background: Between 2004 and 2006, 1,170 Swedish soldiers were deployed to Liberia. They were prescribed mefloquine or atovaquone/proguanil as malaria chemoprophylaxis. Our study aims were to estimate the chemoprophylaxis effectiveness and adverse events. Methods: Cases of malaria were routinely reported during and after the mission. After return to Sweden, the soldiers filled in a questionnaire concerning type of accommodation, use of prophylaxis, and adverse events. Results: No cases of Plasmodium falciparum malaria were recorded during a total of 7,000 person-months. Adverse events (AE) were reported by 57% in the mefloquine group and 34% in the atovaquone/proguanil group. In the mefloquine group, the soldiers reported more neuropsychological AE. Conclusions: Both drugs were safe and 100% effective as lone-term prophylaxis for prevention of P. falciparum malaria. Atovaquone/proguanil was better tolerated with respect to self-reported AE.

Place, publisher, year, edition, pages
2008. Vol. 173, no 12, 1194-1198 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-149297ISI: 000207569700012PubMedID: 19149338OAI: oai:DiVA.org:uu-149297DiVA: diva2:404474
Available from: 2011-03-17 Created: 2011-03-17 Last updated: 2011-03-17Bibliographically approved

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