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The ability of HDL to inhibit VCAM-1 expression and oxidized LDL uptake is impaired in renal patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2008 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 41, no 12, 1015-1018 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: This study examines the ability of HDL from hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients to suppress the expression of adhesion molecules in endothelial cells (ICAM-1, VCAM-1) and in monocytes (LFA-1, VLA-4) and to inhibit the uptake of oxidized LDL by macrophages. Design and methods: Gene expression and the uptake of oxidized LDL were determined in 12 HD patients, 12 CAPD patients and 14 healthy volunteers. Results: HDL from renal patients were less effective than control lipoproteins in reducing VCAM-1 expression. HDL from CAPD patients inhibited LFA-1 expression to the highest extent. The ability of HDL from renal patients to reduce oxidized LDL uptake was lower compared to control group. Conclusions: Decreased ability of HDL to suppress expression of VCAM-1 in endothelial cells and the uptake of oxidized LDL by macrophages can be one of the risk factors for atherosclerosis development in patients with renal failure.

Place, publisher, year, edition, pages
2008. Vol. 41, no 12, 1015-1018 p.
Keyword [en]
high density lipoprotein, adhesion molecules, oxidized low density lipoproteins, renal failure, atherosclerosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-149354DOI: 10.1016/j.clinbiochem.2008.04.019ISI: 000257980700015PubMedID: 18474235OAI: oai:DiVA.org:uu-149354DiVA: diva2:404694
Available from: 2011-03-18 Created: 2011-03-18 Last updated: 2011-03-18Bibliographically approved

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