Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma
2002 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 119, no 1, 122-124 p.Article in journal (Refereed) Published
Hodgkin's lymphoma (HL) is characterized by a few Hodgkin, Reed-Sternberg cells (HRS) surrounded by benign cells. We recently reported that mast cells were the predominant CD30L-positive cells in HL tumours, and that they activate HRS in vitro through CD30L-CD30 interaction. Here, we investigated the clinical importance of mast cell infiltration in the tumours of 123 patients. Tumour specimens were stained with a mast-cell-specific antibody that detects tryptase. Mast cells were detected in virtually every case and increasing numbers of mast cells correlated to nodular sclerosis histology (P = 0.008). Patients with higher mast cell infiltration had a worse relapse-free survival (P = 0.01).
Place, publisher, year, edition, pages
2002. Vol. 119, no 1, 122-124 p.
IdentifiersURN: urn:nbn:se:uu:diva-149402DOI: 10.1046/j.1365-2141.2002.03768.xPubMedID: 12358914OAI: oai:DiVA.org:uu-149402DiVA: diva2:404931