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Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology, Molecular and Morphological Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
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2002 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 119, no 1, 122-124 p.Article in journal (Refereed) Published
Abstract [en]

Hodgkin's lymphoma (HL) is characterized by a few Hodgkin, Reed-Sternberg cells (HRS) surrounded by benign cells. We recently reported that mast cells were the predominant CD30L-positive cells in HL tumours, and that they activate HRS in vitro through CD30L-CD30 interaction. Here, we investigated the clinical importance of mast cell infiltration in the tumours of 123 patients. Tumour specimens were stained with a mast-cell-specific antibody that detects tryptase. Mast cells were detected in virtually every case and increasing numbers of mast cells correlated to nodular sclerosis histology (P = 0.008). Patients with higher mast cell infiltration had a worse relapse-free survival (P = 0.01).

Place, publisher, year, edition, pages
2002. Vol. 119, no 1, 122-124 p.
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Clinical Medicine
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URN: urn:nbn:se:uu:diva-149402DOI: 10.1046/j.1365-2141.2002.03768.xPubMedID: 12358914OAI: oai:DiVA.org:uu-149402DiVA: diva2:404931
Available from: 2011-03-18 Created: 2011-03-18 Last updated: 2017-12-11Bibliographically approved

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Molin, DanielGlimelius, IngridGlimelius, BengtEnblad, Gunilla

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