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Accumulating insoluble protein and rate of aging
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2008 (English)In: Rejuvenation research, ISSN 1549-1684, Vol. 11, no 2, 445-447 p.Article in journal (Refereed) Published
Abstract [en]

It has been proposed that during aging there is a progressive accumulation of insoluble crosslinked protein, which impedes cellular function by excluding macromolecular colloids (e.g., chromosomes and transport vesicles) from part of the water volume. The exponential increase with age in mortality rate, according to the Gompertz law, is correlated with the logarithmic decrease in water volume available to a colloid in a polymer network, according to the Ogston-Laurent equation. The Gompertz slope is proposed to be a measure of the rate of insoluble protein accumulation. According to this model, aging is retarded and life span prolonged by impeding the accumulation of the insoluble protein.

Place, publisher, year, edition, pages
2008. Vol. 11, no 2, 445-447 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-149694DOI: 10.1089/rej.2008.0672ISI: 000255773200026OAI: oai:DiVA.org:uu-149694DiVA: diva2:405273
Conference Information: 3rd Conference on Strategies for Engineered Negligible Senescence (SENS) Queens Coll, Cambridge, ENGLAND, SEP 06-10, 2007 Available from: 2011-03-22 Created: 2011-03-22 Last updated: 2011-03-22Bibliographically approved

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