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Restricted-access media development for direct analysis of drugs in biofluids using capillary liquid chromatography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
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2008 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 391, no 6, 2323-2328 p.Article in journal (Refereed) Published
Abstract [en]

In analytical sciences the design of novel materials and stationary phases for the sample preparation and separation of analytes from biological fluids is needed. In this work we present different strategies for modification of stationary phases to produce tailored solutions for the analytical problem. In this context a novel shielded polymeric reversed-phase monolithic material was prepared in the presence of different numbers of reactive groups and concentrations of the coating polymer. Chromatographic experiments were performed using benzoic acid propyl ester in order to characterize the hydrophobicity and efficiency of the different restricted-access continuous beds prepared. Inverse size-exclusion chromatography was used for investigation of the pore structure properties of the beds. Capillary columns were applied for nanochromatography of biological fluids containing a mixture of nitrazepamum and medazepamum.

Place, publisher, year, edition, pages
2008. Vol. 391, no 6, 2323-2328 p.
Keyword [en]
biofluids, capillary liquid chromatography, continuous beds, monoliths, restricted-access media
National Category
Pharmaceutical Sciences
URN: urn:nbn:se:uu:diva-149657DOI: 10.1007/s00216-008-2024-xISI: 000257200200038OAI: oai:DiVA.org:uu-149657DiVA: diva2:405847
Available from: 2011-03-23 Created: 2011-03-22 Last updated: 2012-05-04Bibliographically approved

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