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Expression of BCR-ABL1 oncogene relative to ABL1 gene changes overtime in chronic myeloid leukemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Hematologi)
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2008 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 366, no 3, 848-851 p.Article in journal (Other (popular science, discussion, etc.)) Published
Abstract [en]

Using a quantitative single nucleotide polymorphism (SNP) assay we have investigated the changes in the expression of the BCR-ABL1 oncogene relative to the wild-type ABL1 and BCR alleles in cells from chronic myeloid leukemia (CML) patients not responding to therapy. The results show a progressive increase in the BCR-ABL1 oncogene expression at the expense of decreased expression of the ABL1 allele, not involved in the fusion. No relative changes in the expression of the two BCR alleles were found. These results demonstrate that allele-specific charities in gene expression, with selective, progressive silencing of the wild-type A BL1 allele in favor of the oncogenic BCR-ABL1 allele occur in CML patients with therapy-resistant disease.

Place, publisher, year, edition, pages
2008. Vol. 366, no 3, 848-851 p.
Keyword [en]
imbalanced allelic expression, quantitative SNP assay, oncogene, BCR-ABL1 expression, disease progression
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-12818DOI: 10.1016/j.bbrc.2007.12.029ISI: 000252518400039OAI: oai:DiVA.org:uu-12818DiVA: diva2:40587
Available from: 2008-01-16 Created: 2008-01-16 Last updated: 2017-12-11Bibliographically approved

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Syvänen, Ann-Christine

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Molecular MedicineDepartment of Genetics and PathologyDepartment of Medical Sciences
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