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Somatostatin induces rapid contraction of neuroendocrine cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrine Oncology.
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2007 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 581, no 10, 1957-1962 p.Article in journal (Refereed) Published
Abstract [en]

The peptide hormone somatostatin, as well as the somatostatin analog octreotide, induces rapid morphological changes in neuroendocrine cells. The effect can be detected in less than 2min: retraction fibers are formed, cells round up and cell–cell contacts are broken. Somatostatin-dependent cell contraction is inhibited by Y-27632, indicating that this effect is dependent on Rho kinase. In BON1 cells, the somatostatin-induced inhibition of forskolin-induced secretion of chromogranin A is not blocked by Y-27632. It is therefore concluded that the inhibitory effect of somatostatin in forskolin-stimulated cells is not dependent on cell contraction.

Place, publisher, year, edition, pages
2007. Vol. 581, no 10, 1957-1962 p.
Keyword [en]
Actin cytoskeleton, Cell contraction, Rho kinase, Secretion, Somatostatin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-12825DOI: 10.1016/j.febslet.2007.04.019ISI: 000246728700005PubMedID: 17462633OAI: oai:DiVA.org:uu-12825DiVA: diva2:40594
Available from: 2008-06-04 Created: 2008-06-04 Last updated: 2017-12-11

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Saras, JanGrönberg, MalinStridsberg, MatsÖberg, Kjell E.Janson, Eva Tiensuu

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