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C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats.
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2004 (English)In: Nephrol Dial Transplant, ISSN 0931-0509, Vol. 19, no 6, 1385-91 p.Article in journal (Other scientific) Published
Abstract [en]

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<Title>Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</Title>

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<ArticleTitle>C-peptide and captopril are equally effective in lowering glomerular hyperfiltration in diabetic rats.</ArticleTitle>

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<AbstractText>BACKGROUND: C-peptide has been shown to reduce glomerular hyperfiltration, glomerular hypertrophy and urinary albumin excretion in type 1 diabetes, but its effect has not been compared with that of an angiotensin-converting enzyme inhibitor (ACEI) in the early stage of renal involvement in diabetes. METHODS: Glomerular filtration rate (GFR) was measured in terms of inulin clearance and renal blood flow, using ultrasound technique, in four groups of streptozotocin-induced diabetic rats before and after a 60 min infusion of C-peptide (D-Cp), captopril (D-ACEI), C-peptide and captopril (D-Cp-ACEI) or placebo (D-placebo). In addition, a non-diabetic control group was studied before and after captopril infusion (C-ACEI). RESULTS: GFR was 37-51% higher in the diabetic groups than in the control animals. GFR decreased after treatment in the D-Cp, D-ACEI and D-Cp-ACEI groups, but did not change in the D-placebo group. Blood flow increased by 26-32% in the three groups receiving captopril and by 5% in the diabetic groups treated with C-peptide alone or placebo. The increase in blood flow in the three ACEI-treated groups was significantly greater than in the D-placebo group. Filtration fraction fell significantly in all groups, but only in the combined D-Cp-ACEI group did it fall significantly more than in the D-placebo group. CONCLUSIONS: C-peptide and captopril lower diabetes-induced glomerular hyperfiltration to a similar extent, but the influence of captopril on blood flow is greater than that of C-peptide, suggesting different mechanisms of action. No statistically significant additive effects of C-peptide and captopril were shown in this acute infusion study.</AbstractText>

</Abstract>

<Affiliation>Department of Nephrology, Danderyd Hospital, SE-182 88 Stockholm, Sweden. bjorn.samnegard@medks.ki.se</Affiliation>

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<LastName>Jacobson</LastName>

<ForeName>Stefan H</ForeName>

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<LastName>Johansson</LastName>

<ForeName>Bo-Lennart</ForeName>

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<LastName>Ekberg</LastName>

<ForeName>Karin</ForeName>

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<LastName>Isaksson</LastName>

<ForeName>Britta</ForeName>

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<LastName>Wahren</LastName>

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<DescriptorName MajorTopicYN="N">Angiotensin-Converting Enzyme Inhibitors</DescriptorName>

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<MeshHeading>

<DescriptorName MajorTopicYN="N">Animals</DescriptorName>

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<MeshHeading>

<DescriptorName MajorTopicYN="N">C-Peptide</DescriptorName>

<QualifierName MajorTopicYN="Y">pharmacology</QualifierName>

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<MeshHeading>

<DescriptorName MajorTopicYN="N">Captopril</DescriptorName>

<QualifierName MajorTopicYN="Y">pharmacology</QualifierName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Diabetes Mellitus, Experimental</DescriptorName>

<QualifierName MajorTopicYN="Y">physiopathology</QualifierName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Glomerular Filtration Rate</DescriptorName>

<QualifierName MajorTopicYN="Y">drug effects</QualifierName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Kidney Glomerulus</DescriptorName>

<QualifierName MajorTopicYN="Y">drug effects</QualifierName>

<QualifierName MajorTopicYN="Y">physiopathology</QualifierName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Male</DescriptorName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Rats</DescriptorName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>

</MeshHeading>

<MeshHeading>

<DescriptorName MajorTopicYN="N">Regional Blood Flow</DescriptorName>

<QualifierName MajorTopicYN="N">drug effects</QualifierName>

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Place, publisher, year, edition, pages
2004. Vol. 19, no 6, 1385-91 p.
Keyword [en]
Angiotensin-Converting Enzyme Inhibitors/*pharmacology, Animals, C-Peptide/*pharmacology, Captopril/*pharmacology, Diabetes Mellitus; Experimental/*physiopathology, Glomerular Filtration Rate/*drug effects, Kidney Glomerulus/*drug effects/*physiopathology, Male, Rats, Rats; Sprague-Dawley, Regional Blood Flow/drug effects
Identifiers
URN: urn:nbn:se:uu:diva-12867PubMedID: 15004258OAI: oai:DiVA.org:uu-12867DiVA: diva2:40637
Note
Samnegård B, Jacobson SH, Johansson BL, Ekberg K, Isaksson B, Wahren J, Sjöquist M. Department of Nephrology, Danderyd Hospital, SE-182 88 Stockholm, Sweden. bjorn.samnegard@medks.ki.se BACKGROUND: C-peptide has been shown to reduce glomerular hyperfiltration, glomerular hypertrophy and urinary albumin excretion in type 1 diabetes, but its effect has not been compared with that of an angiotensin-converting enzyme inhibitor (ACEI) in the early stage of renal involvement in diabetes. METHODS: Glomerular filtration rate (GFR) was measured in terms of inulin clearance and renal blood flow, using ultrasound technique, in four groups of streptozotocin-induced diabetic rats before and after a 60 min infusion of C-peptide (D-Cp), captopril (D-ACEI), C-peptide and captopril (D-Cp-ACEI) or placebo (D-placebo). In addition, a non-diabetic control group was studied before and after captopril infusion (C-ACEI). RESULTS: GFR was 37-51% higher in the diabetic groups than in the control animals. GFR decreased after treatment in the D-Cp, D-ACEI and D-Cp-ACEI groups, but did not change in the D-placebo group. Blood flow increased by 26-32% in the three groups receiving captopril and by 5% in the diabetic groups treated with C-peptide alone or placebo. The increase in blood flow in the three ACEI-treated groups was significantly greater than in the D-placebo group. Filtration fraction fell significantly in all groups, but only in the combined D-Cp-ACEI group did it fall significantly more than in the D-placebo group. CONCLUSIONS: C-peptide and captopril lower diabetes-induced glomerular hyperfiltration to a similar extent, but the influence of captopril on blood flow is greater than that of C-peptide, suggesting different mechanisms of action. No statistically significant additive effects of C-peptide and captopril were shown in this acute infusion study. PMID: 15004258 [PubMed - indexed for MEDLINE]Available from: 2008-01-18 Created: 2008-01-18 Last updated: 2011-01-12

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