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Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
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2007 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 43, no 9, 1348-1360 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this article is to present updated guidelines for the use of serum, tissue and faecal markers in colorectal cancer (CRC). Lack of specificity and sensitivity preclude the use of all existing serum markers for the early detection of CRC. For patients with stage Il or stage III CRC who may be candidates for either liver resection or systemic treatment should recurrence develop, CEA should be measured every 2-3 months for at least 3 years after diagnosis. insufficient evidence exists to recommend routine use of tissue factors such as thymidylate synthase, microsatellite instability (MSI), p53, K-ras and deleted in colon cancer (DCC) for either determining prognosis or predicting response to therapy in patients with CRC. Microsatellite instability, however, may be used as a pre-screen for patients with suspected hereditary non-polyposis colorectal cancer. Faecal occult blood testing but not faecal DNA markers may be used to screen asymptomatic subjects 50 years or older for early CRC.

Place, publisher, year, edition, pages
2007. Vol. 43, no 9, 1348-1360 p.
Keyword [en]
colorectal cancer, CEA, guidelines, tumour markers, EGTM
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-150072DOI: 10.1016/j.ejca.2007.03.021ISI: 000248089900016PubMedID: 17512720OAI: oai:DiVA.org:uu-150072DiVA: diva2:406394
Available from: 2011-03-25 Created: 2011-03-25 Last updated: 2011-03-25Bibliographically approved

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