Acquired aplastic anaemia in seven children with severe hepatitis with or without liver failure
2007 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 96, no 11, 1660-1664 p.Article in journal (Refereed) Published
Aim: Aplastic anaemia following hepatitis may develop in as many as 1 of 3 patients with non-A, non-B and non-C hepatitis. Several causative factors have been discussed, such as viral infections and autoimmunity. Here we describe the natural history of this condition in 7 children and investigate possible hepatitis-causing agents. Methods: We reviewed the medical records, bone marrow and liver biopsies of 7 children with severe hepatitis, with or without liver failure, who subsequently had developed aplastic anaemia. Results: The median time from onset of hepatic symptoms until diagnosed onset of aplasia was 54 days. No associated viral infections could be identified. On liver biopsy, a majority had lobular inflammation but lacked signs of autoimmune hepatitis, findings compatible with a viral aetiology. Three of 6 children had low reticulocyte counts already at onset of hepatitis. All, but one patient is alive at median follow-up of 8 years. Conclusion: The unknown pathogenetic mechanism appears to target liver and bone marrow simultaneously, because half of the children concomitantly had low reticulocyte counts and severe liver failure.
Place, publisher, year, edition, pages
2007. Vol. 96, no 11, 1660-1664 p.
aplastic anaemia, hepatitis, liver failure, virus infection
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-150059DOI: 10.1111/j.1651-2227.2007.00491.xISI: 000250261500020PubMedID: 17888058OAI: oai:DiVA.org:uu-150059DiVA: diva2:406438