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The immunoglobulin genes: Structure and specificity in chronic lymphocytic leukemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
2007 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, Vol. 48, no 6, 1081-1086 p.Article, review/survey (Refereed) Published
Abstract [en]

The rearrangement of the immunoglobulin genes (IG) provides a large diversity of B-cell receptors conformations and allows the immune system to respond differently to foreign antigens. In chronic lymphocytic leukemia (CLL), there are a restricted number of stereotyped B-cell receptors rearranged by the tumor B-cells between CLL patients. These subsets with stereotyped receptors appear to have clinical implications, for example cases that rearrange the IGHV3-21 gene display poor clinical prognosis. The number of subsets with stereotyped receptors has been reported at a frequency of over 20% of CLL cases; however, the specificities of these receptors are still not clearly defined. Reactivity to epitopes from bacterial antigen, cytoskeleton components such as vimentin, and antigens on viable and apoptotic T-cell have been proposed. The role of antigen in CLL development is currently being more clearly defined with identification of stereotyped receptors, and their antigen specificity and the continued role antigen stimulation plays in CLL disease will be an important question in the future.

Place, publisher, year, edition, pages
2007. Vol. 48, no 6, 1081-1086 p.
Keyword [en]
immunoglobulin genes, chronic lymphocytic leukemia, stereotyped receptors, antigen specificity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-150160DOI: 10.1080/10428190701342034ISI: 000247779100008OAI: oai:DiVA.org:uu-150160DiVA: diva2:406836
Available from: 2011-03-28 Created: 2011-03-25 Last updated: 2011-03-28Bibliographically approved

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