uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Demonstration of immunoglobulin G with affinity for dopamine in cerebrospinal fluid from psychotic patients.
Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of Göteborg.
Department of Psychiatry and Neurochemistry, University of Lund.
Department of Psychiatry, Sahlgren Hospital, University of Göteborg.
Department of Clinical Neuroscience, Section of Psychiatry and Neurochemistry, University of Göteborg.
1993 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 217, no 2, 129-42 p.Article in journal (Refereed) Published
Abstract [en]

Using an enzyme-linked immunosorbent assay, significantly raised concentrations of immunoglobulin G with affinity for the neurotransmitter dopamine were demonstrated in cerebrospinal fluid from psychotic patients. We have varied the antigen presentation in order to find a conjugate with low unspecific binding. The conjugation of dopamine to carbodiimide-activated poly-L-glutamic acid and that to activated succinimide ester of biotin are described. The use of glutaraldehyde conjugation is not recommended because of the risk of formation of tetrahydroisoquinolines. A strong correlation (r = 0.94, P < 0.001) between the results obtained with dopamine conjugated to poly-L-glutamic acid and dopamine conjugated to biotin was observed. Forty-two human cerebrospinal fluid samples from 20 psychotic patients, (12 with a bipolar disorder and 8 with schizophrenia) and 22 control patients, with various neurological diseases but no apparent psychiatric diseases were investigated. A significantly higher incidence (P < 0.001) of antibodies with affinity for dopamine were found in the group of psychotic patients compared with the neurological control group.

Place, publisher, year, edition, pages
1993. Vol. 217, no 2, 129-42 p.
Identifiers
URN: urn:nbn:se:uu:diva-150345PubMedID: 8261622OAI: oai:DiVA.org:uu-150345DiVA: diva2:407034
Available from: 2011-03-29 Created: 2011-03-29 Last updated: 2017-12-11

Open Access in DiVA

No full text

PubMed

Authority records BETA

Bergquist, Jonas

Search in DiVA

By author/editor
Bergquist, Jonas
In the same journal
Clinica Chimica Acta

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 773 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf