uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Structure-activity relationships for unsaturated dialdehydes 8( *). Comparative effects of 10 sesquiterpenoids on the sea urchin gamete fertilization.
Unité INSERM 303, BP no. 3, 06230 Villefranche-sur-Mer, France.
Unité INSERM 303, BP no. 3, 06230 Villefranche-sur-Mer, France.
Unité INSERM 303, BP no. 3, 06230 Villefranche-sur-Mer, France.
Department of Organic Chemistry 2, Chemical Center, University of Lund.
Show others and affiliations
1993 (English)In: Toxicology in Vitro, ISSN 0887-2333, E-ISSN 1879-3177, Vol. 7, no 3, 205-12 p.Article in journal (Refereed) Published
Abstract [en]

The effects of 10 sesquiterpenoids with unsaturated dialdehyde functionalities were studied on fertilization, first cleavage, and calcium permeability of egg membranes of sea urchin gametes. Fertilization was inhibited by nine compounds when sperm was exposed and by five compounds when eggs were exposed (50 mug/ml for 5 min). All compounds except one (9alpha-hydroxymerulidial) inhibited the first cleavage in a dose-response manner. Only one compound (velleral) increased the Ca(2+) permeability of egg membranes at 20 mug/ml. All compounds reduced to a varying extent the ATP-driven Ca(2+) sequestration by non-mitochondrial intracellular compartments. In general, when hydroxylated and non-hydroxylated derivatives of the compounds are compared, the hydroxylated ones present a lower toxicity when measuring fertilization and cleavage inhibition, and reduction of intracellular Ca(2+) sequestration.

Place, publisher, year, edition, pages
1993. Vol. 7, no 3, 205-12 p.
Identifiers
URN: urn:nbn:se:uu:diva-150348PubMedID: 20732190OAI: oai:DiVA.org:uu-150348DiVA: diva2:407041
Available from: 2011-03-29 Created: 2011-03-29 Last updated: 2017-12-11

Open Access in DiVA

No full text

PubMed

Authority records BETA

Bergquist, Jonas

Search in DiVA

By author/editor
Bergquist, Jonas
In the same journal
Toxicology in Vitro

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 748 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf