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The type I interferon system in the development of lupus
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Systemisk Autoimmunitet, Systemic Autoimmunity)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Systemisk Autoimmunitet, Systemic Autoimmunity)
2011 (English)In: Seminars in Immunology, ISSN 1044-5323, E-ISSN 1096-3618, Vol. 23, no 2, 113-121 p.Article, review/survey (Refereed) Published
Abstract [en]

The type I interferon (IFN) system induces inhibition of viral replication, but can also activate the innate and adaptive immune system. An important role of the type I IFN system in autoimmune diseases, including lupus, is suggested by the observation that these disorders display a prominent over-expression of type I IFN regulated genes. The development of autoimmune diseases in some individuals treated with IFN-α directly supports a pivotal role for this cytokine in breaking tolerance and inducing autoimmune reactions. A genetic setup that promotes type I IFN production and/or response and the presence of endogenous inducers of IFN-α production have been described in patients with lupus. Several known environmental risk factors for development of lupus or disease flares may contribute to the ongoing type I IFN production. In the present review we will describe the possible role of the type I IFN system in the lupus disease process. The possible connection between the type I IFN system and some environmental and genetic risk factors for lupus is also discussed.

Place, publisher, year, edition, pages
2011. Vol. 23, no 2, 113-121 p.
Keyword [en]
Interferon, Lupus, Plasmacytoid dendritic cell, Immune complex, Gene, Environment
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:uu:diva-150414DOI: 10.1016/j.smim.2011.01.009ISI: 000289497000007PubMedID: 21292501OAI: oai:DiVA.org:uu-150414DiVA: diva2:407316
Available from: 2011-03-30 Created: 2011-03-30 Last updated: 2017-12-11Bibliographically approved

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Rönnblom, LarsEloranta, Maija-Leena

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