The type I interferon system in the development of lupus
2011 (English)In: Seminars in Immunology, ISSN 1044-5323, E-ISSN 1096-3618, Vol. 23, no 2, 113-121 p.Article, review/survey (Refereed) Published
The type I interferon (IFN) system induces inhibition of viral replication, but can also activate the innate and adaptive immune system. An important role of the type I IFN system in autoimmune diseases, including lupus, is suggested by the observation that these disorders display a prominent over-expression of type I IFN regulated genes. The development of autoimmune diseases in some individuals treated with IFN-α directly supports a pivotal role for this cytokine in breaking tolerance and inducing autoimmune reactions. A genetic setup that promotes type I IFN production and/or response and the presence of endogenous inducers of IFN-α production have been described in patients with lupus. Several known environmental risk factors for development of lupus or disease flares may contribute to the ongoing type I IFN production. In the present review we will describe the possible role of the type I IFN system in the lupus disease process. The possible connection between the type I IFN system and some environmental and genetic risk factors for lupus is also discussed.
Place, publisher, year, edition, pages
2011. Vol. 23, no 2, 113-121 p.
Interferon, Lupus, Plasmacytoid dendritic cell, Immune complex, Gene, Environment
Medical and Health Sciences
Research subject Medicine
IdentifiersURN: urn:nbn:se:uu:diva-150414DOI: 10.1016/j.smim.2011.01.009ISI: 000289497000007PubMedID: 21292501OAI: oai:DiVA.org:uu-150414DiVA: diva2:407316