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Increased dopamine content in lymphocytes from high-dose L-Dopa-treated Parkinson's disease patients
Department of Neurology, University of Szeged and cInstitute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Göteborg University, Sahlgrenska University Hospital Mölndal.
Department of Neurology, University of Szeged.
Department of Neurology, University of Szeged and Neurology Research Group of the Hungarian Academy of Sciences and University of Szeged, Szeged, Hungary.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Analytical Chemistry.
2005 (English)In: Neuroimmunomodulation, ISSN 1021-7401, E-ISSN 1423-0216, Vol. 12, no 2, 81-84 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The intracellular (i.c.) content of dopamine and its metabolites was measured in the peripheral blood lymphocytes (PBLs) of Parkinson's disease (PD) patients and healthy controls. METHODS: Catecholamine levels of PBLs were measured using capillary electrophoresis in healthy controls and PD patients receiving different doses of L-dihydroxyphenylalanine (L-Dopa). RESULTS: Higher i.c. dopamine content was found in lymphocytes from PD patients receiving a high dose of L-Dopa (700 +/- 30 mg/day) as compared to lymphocytes from the healthy controls (p = 0.002) and from PD patients treated with a low dose of L-Dopa (400 +/- 30 mg/day) (p = 0.022). The dihydroxyphenylacetic acid to dopamine ratio was significantly lower in the high-dose L-Dopa-treated PD patients than in the controls (p = 0.013). CONCLUSIONS: These findings suggest that the dopamine content and metabolism in the peripheral lymphocytes of PD patients are influenced by L-Dopa administration. This is the first study in which a dose-related effect of L-Dopa treatment was found in lymphocytes from PD patients.

Place, publisher, year, edition, pages
2005. Vol. 12, no 2, 81-84 p.
Keyword [en]
capillary electrophoresis, catecholamine, dopamine, Parkinson's disease, peripheral blood lymphocytes
National Category
Medical and Health Sciences Chemical Sciences
URN: urn:nbn:se:uu:diva-150438DOI: 10.1159/000083579PubMedID: 15785109OAI: oai:DiVA.org:uu-150438DiVA: diva2:407374
Available from: 2011-03-30 Created: 2011-03-30 Last updated: 2011-04-05Bibliographically approved

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