Increased dopamine content in lymphocytes from high-dose L-Dopa-treated Parkinson's disease patients
2005 (English)In: Neuroimmunomodulation, ISSN 1021-7401, E-ISSN 1423-0216, Vol. 12, no 2, 81-84 p.Article in journal (Refereed) Published
OBJECTIVES: The intracellular (i.c.) content of dopamine and its metabolites was measured in the peripheral blood lymphocytes (PBLs) of Parkinson's disease (PD) patients and healthy controls. METHODS: Catecholamine levels of PBLs were measured using capillary electrophoresis in healthy controls and PD patients receiving different doses of L-dihydroxyphenylalanine (L-Dopa). RESULTS: Higher i.c. dopamine content was found in lymphocytes from PD patients receiving a high dose of L-Dopa (700 +/- 30 mg/day) as compared to lymphocytes from the healthy controls (p = 0.002) and from PD patients treated with a low dose of L-Dopa (400 +/- 30 mg/day) (p = 0.022). The dihydroxyphenylacetic acid to dopamine ratio was significantly lower in the high-dose L-Dopa-treated PD patients than in the controls (p = 0.013). CONCLUSIONS: These findings suggest that the dopamine content and metabolism in the peripheral lymphocytes of PD patients are influenced by L-Dopa administration. This is the first study in which a dose-related effect of L-Dopa treatment was found in lymphocytes from PD patients.
Place, publisher, year, edition, pages
2005. Vol. 12, no 2, 81-84 p.
capillary electrophoresis, catecholamine, dopamine, Parkinson's disease, peripheral blood lymphocytes
Medical and Health Sciences Chemical Sciences
IdentifiersURN: urn:nbn:se:uu:diva-150438DOI: 10.1159/000083579PubMedID: 15785109OAI: oai:DiVA.org:uu-150438DiVA: diva2:407374