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RNA antitoxins
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. (Wagner)
2007 (English)In: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 10, no 2, p. 117-124Article, review/survey (Refereed) Published
Abstract [en]

Recent genomic analyses revealed a surprisingly large number of toxin–antitoxin loci in free-living prokaryotes. The antitoxins are proteins or antisense RNAs that counteract the toxins. Two antisense RNA-regulated toxin–antitoxin gene families, hok/sok and ldr, are unrelated sequence-wise but have strikingly similar properties at the level of gene and RNA organization. Recently, two SOS-induced toxins were found to be regulated by RNA antitoxins. One such toxin, SymE, exhibits similarity with MazE antitoxin and, surprisingly, inhibits translation. Thus, it is possible that an ancestral antitoxin gene evolved into the present toxin gene (symE) whose translation is repressed by an RNA antitoxin (SymR).

Place, publisher, year, edition, pages
2007. Vol. 10, no 2, p. 117-124
Keywords [en]
Bacteria/*genetics/metabolism, Bacterial Proteins/genetics/metabolism, Bacterial Toxins/*antagonists & inhibitors/*metabolism, DNA-Binding Proteins/metabolism, Escherichia coli/genetics/metabolism, Escherichia coli Proteins/metabolism, Plasmids, RNA/*genetics, RNA; Antisense/*metabolism, RNA; Bacterial/*metabolism
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-12968DOI: 10.1016/j.mib.2007.03.003ISI: 000246349600006PubMedID: 17376733OAI: oai:DiVA.org:uu-12968DiVA, id: diva2:40738
Available from: 2008-05-29 Created: 2008-05-29 Last updated: 2017-12-11Bibliographically approved

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Wagner, Gerhart H.

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