Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma
2007 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 138, no 1, 68-71 p.Article in journal (Refereed) Published
Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.
Place, publisher, year, edition, pages
2007. Vol. 138, no 1, 68-71 p.
Aged, Biological Markers/analysis, Cell Movement, Disease-Free Survival, Female, Humans, Immunohistochemistry, Lymphoma; Large B-Cell; Diffuse/*immunology, Male, Mast Cells/enzymology/*pathology, Middle Aged, Prognosis, Proportional Hazards Models, Statistics; Nonparametric, Survival Analysis, Tryptases/analysis
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-12998DOI: 10.1111/j.1365-2141.2007.06612.xISI: 000247111300006PubMedID: 17555448OAI: oai:DiVA.org:uu-12998DiVA: diva2:40768