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B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2008 (English)In: Cancer Letters, ISSN 0304-3835, Vol. 259, no 2, 138-145 p.Article in journal (Refereed) Published
Abstract [en]

To study the differential expression of cell membrane-bound receptors and their potential role in growth and/or survival of the tumor cells, highly purified follicular lymphoma cells were analyzed, using gene expression analysis, and compared to non-malignant B cell populations. Filtering the genome for overexpressed genes coding for cell membrane-bound proteins/receptors resulted in a hit list of 27 identified genes. Among these, we have focused on the aberrant over expression of CX3CR1, in different types of B cell lymphoma, as compared to non-malignant B cells. We show that CX3CR1, which normally is not expressed on B cells, is expressed both at the mRNA and protein level in several subtypes of lymphoma. CX3CR1 has also shown to be involved in the homing to specific tissues that express the ligand, CX3CL1, in breast and prostate cancer and may thus be involved in dissemination of lymphoma.

Place, publisher, year, edition, pages
2008. Vol. 259, no 2, 138-145 p.
Keyword [en]
Follicular lymphoma, Metastasis, Receptor, Gene expression
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-13006DOI: 10.1016/j.canlet.2007.10.031ISI: 000253023100002PubMedID: 18060687OAI: oai:DiVA.org:uu-13006DiVA: diva2:40776
Available from: 2008-01-20 Created: 2008-01-20 Last updated: 2010-01-13Bibliographically approved

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Rosenquist, Richard
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