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From glutamate co-release to vesicular synergy: vesicular glutamate transporters
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
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2011 (English)In: Nature Reviews Neuroscience, ISSN 1471-003X, E-ISSN 1471-0048, Vol. 12, no 4, 204-216 p.Article, review/survey (Refereed) Published
Abstract [en]

Recent data indicate that 'classical' neurotransmitters can also act as co-transmitters. This notion has been strengthened by the demonstration that three vesicular glutamate transporters (vesicular glutamate transporter 1 (VGLUT1), VGLUT2 and VGLUT3) are present in central monoamine, acetylcholine and GABA neurons, as well as in primarily glutamatergic neurons. Thus, intriguing questions are raised about the morphological and functional organization of neuronal systems endowed with such a dual signalling capacity. In addition to glutamate co-release, vesicular synergy - a process leading to enhanced packaging of the 'primary' transmitter - is increasingly recognized as a major property of the glutamatergic co-phenotype. The behavioural relevance of this co-phenotype is presently the focus of considerable interest.

Place, publisher, year, edition, pages
2011. Vol. 12, no 4, 204-216 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-150728DOI: 10.1038/nrn2969ISI: 000288535600010PubMedID: 21415847OAI: oai:DiVA.org:uu-150728DiVA: diva2:408536
Available from: 2011-04-05 Created: 2011-04-05 Last updated: 2016-05-11Bibliographically approved

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