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Acetylation status does not affect levosimendan's hemodynamic effects in heart failure patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2011 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 45, no 2, 86-90 p.Article in journal (Refereed) Published
Abstract [en]

Objective. Levosimendan is indicated for acute heart failure. The formation of levosimendan's active metabolite OR-1896 is dependent on the acetylator status. We evaluated whether acetylator status affects the hemodynamic responses after levosimendan infusion. Methods. Forty-one NYHA III to IV heart failure patients were divided into rapid and slow acetylators by population kinetic modeling. Invasive hemodynamics and plasma concentrations of levosimendan and its metabolites were followed serially. Results. Fifty-six percent of the patients were rapid and 44% slow acetylators. Levosimendan induced increases in heart rate and cardiac output, and decreases in pulmonary capillary wedge pressure (PCWP) and blood pressure, which were sustained at 24 hours after stopping the infusion. At this time, levosimendan levels were undetectable, and OR-1896 levels were about two-fold higher in rapid acetylators. However, hemodynamic effects were similar; mean(SEM) change from baseline in cardiac output was ++2.0(0.3) vs. ++1.6(0.3) l/min (p == 0.309), and in PCWP --8(2) vs. --7(1) mmHg (p == 0.536), in rapid and slow acetylators, respectively. Conclusion. The sustained hemodynamic effects of levosimendan are similar irrespective of acetylator status.

Place, publisher, year, edition, pages
2011. Vol. 45, no 2, 86-90 p.
Keyword [en]
Levosimendan, acetylator status, hemodynamics, heart failure
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-150717DOI: 10.3109/14017431.2010.540762ISI: 000288326200004PubMedID: 21133820OAI: oai:DiVA.org:uu-150717DiVA: diva2:408582
Available from: 2011-04-05 Created: 2011-04-05 Last updated: 2011-04-05Bibliographically approved

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