MLGA--a rapid and cost-efficient assay for gene copy-number analysis
2007 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 35, no 17, e115- p.Article in journal (Refereed) Published
Structural variation is an important cause of genetic variation. Whole genome analysis techniques can efficiently identify copy-number variable regions but there is a need for targeted methods, to verify and accurately size variable regions, and to diagnose large sample cohorts. We have developed a technique based on multiplex amplification of size-coded selectively circularized genomic fragments, which is robust, cheaper and more rapid than current multiplex targeted copy-number assays.
Place, publisher, year, edition, pages
2007. Vol. 35, no 17, e115- p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-13111DOI: 10.1093/nar/gkm651ISI: 000250683500008PubMedID: 17823203OAI: oai:DiVA.org:uu-13111DiVA: diva2:40881