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Transforming growth factor beta-1 enhances cytotoxic effect of doxorubicin in human lung adenocarcinoma cells of A549 line
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2007 (English)In: Cell Biology International, ISSN 1065-6995, E-ISSN 1095-8355, Vol. 31, no 8, 851-855 p.Article in journal (Refereed) Published
Abstract [en]

Transforming growth factor beta-1 (TGFbeta-1) is a regulator of cell proliferation, differentiation and apoptosis. Doxorubicin (adriamycin), an anthracycline drug causing double-strand DNA breaks, is widely used in anticancer chemotherapy. Here we demonstrated that TGFbeta-1 enhanced cytotoxic (proapoptotic) action of doxorubicin towards cultured human lung carcinoma A549 cells. Western-blot analysis and immunocytochemistry were used to show that doxorubicin induced PARP degradation in A549 cells, and TGFbeta-1 enhanced that action of the drug. The obtained results suggest a possibility of biomodulating effect of TGFbeta-1 on tumor cell treatment with doxorubicin.

Place, publisher, year, edition, pages
2007. Vol. 31, no 8, 851-855 p.
Keyword [en]
doxorubicin, TGFbeta-1, apoptosis, human lung adenocarcinoma A549 cells
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-150840DOI: 10.1016/j.cellbi.2007.02.008ISI: 000247316800014PubMedID: 17418594OAI: oai:DiVA.org:uu-150840DiVA: diva2:409087
Available from: 2011-04-07 Created: 2011-04-06 Last updated: 2011-04-07Bibliographically approved

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