Transforming growth factor beta-1 enhances cytotoxic effect of doxorubicin in human lung adenocarcinoma cells of A549 line
2007 (English)In: Cell Biology International, ISSN 1065-6995, E-ISSN 1095-8355, Vol. 31, no 8, 851-855 p.Article in journal (Refereed) Published
Transforming growth factor beta-1 (TGFbeta-1) is a regulator of cell proliferation, differentiation and apoptosis. Doxorubicin (adriamycin), an anthracycline drug causing double-strand DNA breaks, is widely used in anticancer chemotherapy. Here we demonstrated that TGFbeta-1 enhanced cytotoxic (proapoptotic) action of doxorubicin towards cultured human lung carcinoma A549 cells. Western-blot analysis and immunocytochemistry were used to show that doxorubicin induced PARP degradation in A549 cells, and TGFbeta-1 enhanced that action of the drug. The obtained results suggest a possibility of biomodulating effect of TGFbeta-1 on tumor cell treatment with doxorubicin.
Place, publisher, year, edition, pages
2007. Vol. 31, no 8, 851-855 p.
doxorubicin, TGFbeta-1, apoptosis, human lung adenocarcinoma A549 cells
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-150840DOI: 10.1016/j.cellbi.2007.02.008ISI: 000247316800014PubMedID: 17418594OAI: oai:DiVA.org:uu-150840DiVA: diva2:409087