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A polyclonal antiserum against chromogranin A and B: a new sensitive marker for neuroendocrine tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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1990 (English)In: Acta Endocrinologica, ISSN 0001-5598, Vol. 122, no 2, 145-155 p.Article in journal (Refereed) Published
Abstract [en]

Chromogranins A, B, and C, proteins that are co-stored and co-released with peptides and amines, have been identified in a variety of neuroendocrine tissues, both normal and neoplastic. We examined the secretion of chromogranin A and chromogranin A + B by hormone-producing tumours in patients with endocrine pancreatic tumours, carcinoid tumours, pheochromocytomas, and small cell lung cancer. The radioimmunoassay determining the plasma concentrations of chromogranin A + B showed a greater sensitivity than that determining chromogranin A alone. All patients with endocrine pancreatic tumours, carcinoids, and pheochromocytomas had increased levels of chromograin A + B, whereas a small number of the patients (5/18 with endocrine pancreatic tumours and with pheochromocytomas) had normal levels of chromogranin A. Also in immunocytochemical stainings, our polyclonal antiserum detecting both chromogranin A and B showed a greater sensitivity than other available antisera against chromogranin A, B and C. We have demonstrated that a polyclonal antiserum against a mixture of chromogranin A and B might be a more sensitive marker than chromogranin A alone for diagnosing neuroendocrine tumours. This is not surprising, since both chromogranins are widely distributed in neuroendocrine cells.

Place, publisher, year, edition, pages
1990. Vol. 122, no 2, 145-155 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-150951DOI: 10.1530/acta.0.1220145OAI: oai:DiVA.org:uu-150951DiVA: diva2:409453
Available from: 2011-04-08 Created: 2011-04-08 Last updated: 2011-04-21Bibliographically approved

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