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Services for prediction of drug susceptibility for HIV proteases and reverse transcriptases at the HIV Drug Research Centre
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0002-8083-2864
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2011 (English)In: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 27, no 12, 1719-1720 p.Article in journal (Refereed) Published
Abstract [en]

Summary: The HIV Drug Research Centre (HIVDRC) has established Web services for prediction of drug susceptibility for HIV proteases and reverse transcriptases. The services are based on two proteochemometric models which accepts a protease or reverse transcriptase sequence in amino acid form, and outputs the predicted drug susceptibility values. The predictions are based on a comprehensive analysis where all the relevant inhibitors are included, resulting in models with excellent predictive capabilities.

Availability and Implementation: The services are implemented as interoperable Web services (REST and XMPP), with supporting web pages to allow for individual analyses. A set of plugins were also developed which make the services available from the Bioclipse workbench for life science. Services are available athttp://www.hivdrc.org/services.

Place, publisher, year, edition, pages
Oxford: Oxford University Press , 2011. Vol. 27, no 12, 1719-1720 p.
Keyword [en]
hiv, bioclipse, susceptibility, services
National Category
Pharmacology and Toxicology
Research subject
Bioinformatics
Identifiers
URN: urn:nbn:se:uu:diva-151000DOI: 10.1093/bioinformatics/btr192ISI: 000291261300027OAI: oai:DiVA.org:uu-151000DiVA: diva2:409632
Available from: 2011-04-09 Created: 2011-04-09 Last updated: 2017-12-11Bibliographically approved

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Spjuth, OlaEklund, MartinLapins, MarisWikberg, Jarl

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