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Propofol mitigates systemic oxidative injury during experimental cardiopulmonary cerebral resuscitation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2011 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 84, no 5-6, 123-130 p.Article in journal (Refereed) Published
Abstract [en]

Effects of propofol, an intravenous anesthetic agent that exerts potent antioxidant properties, were investigated in an experimental model of cardiac arrest and cardiopulmonary resuscitation. An extended cardiac arrest with 15 randomized piglets was studied to assess the effect of propofol or its solvent intralipid as the control group. Oxidative stress (as measured by a major F(2)-isoprostane) and inflammation (a major metabolite of PGF(2α)) were evaluated in addition to the hemodynamic evaluation, protein S-100β and in situ tissue brain damage by immunochemistry at sacrifice after 3h of reperfusion following cardiac arrest and restoration of spontaneous circulation (ROSC). ROSC increased jugular bulb plasma levels of F(2)-isoprostane and PGF(2α) metabolite significantly more in controls than in the propofol-treated group. In situ tissue damage after ischemia-reperfusion was variable among the pigs at sacrifice, but tended to be greater in the control than the propofol-treated group. Propofol significantly reduced an ROSC-mediated oxidative stress in the brain.

Place, publisher, year, edition, pages
2011. Vol. 84, no 5-6, 123-130 p.
Keyword [en]
Ischemia-reperfusion, Prostaglandins, Isoprostanes, Oxidative stress, CPR, Brain, ROSC
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-151377DOI: 10.1016/j.plefa.2010.11.006ISI: 000290079400001PubMedID: 21316209OAI: oai:DiVA.org:uu-151377DiVA: diva2:409699
Available from: 2011-04-11 Created: 2011-04-11 Last updated: 2017-12-11Bibliographically approved

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Miclescu, AdrianaSharma, Hari ShankerWiklund, Lars

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