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Validation of Bohr dead space measured by volumetric capnography
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
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2011 (English)In: Intensive Care Medicine, ISSN 0342-4642, E-ISSN 1432-1238, Vol. 37, no 5, 870-874 p.Article in journal (Refereed) Published
Abstract [en]

Bohr's dead space (VDBohr) is commonly calculated using end-tidal CO2 instead of the true alveolar partial pressure of CO2 (PACO(2)). The aim of this work was to validate VDBohr using PACO(2) derived from volumetric capnography (VC) against VDBohr with PACO(2) values obtained from the standard alveolar air formula.

Expired gases of seven lung-lavaged pigs were analyzed at different lung conditions using main-stream VC and multiple inert gas elimination technique (MIGET). PACO(2) was determined by VC as the midpoint of the slope of phase III of the capnogram, while mean expired partial pressure of CO2 (PeCO(2)) was calculated as the mean expired fraction of CO2 times the barometric minus the water vapor pressure. MIGET estimated expired CO2 output (VCO2) and PeCO(2) by its V/Q algorithms. Then, PACO(2) was obtained applying the alveolar air formula (PACO(2) = VCO2/alveolar ventilation).

We found close linear correlations between the two methods for calculating both PACO(2) (r = 0.99) and VDBohr (r = 0.96), respectively (both p < 0.0001). Mean PACO(2) from VC was very similar to the one obtained by MIGET with a mean bias of -0.10 mmHg and limits of agreement between -2.18 and 1.98 mmHg. Mean VDBohr from VC was close to the value obtained by MIGET with a mean bias of 0.010 ml and limits of agreement between -0.044 and 0.064 ml.

VDBohr can be calculated with accuracy using volumetric capnography.

Place, publisher, year, edition, pages
2011. Vol. 37, no 5, 870-874 p.
Keyword [en]
Volumetric capnography, PACO(2), Bohr's dead space, Carbon dioxide, Tidal volume, Gas exchange
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-151481DOI: 10.1007/s00134-011-2164-xISI: 000289291900020PubMedID: 21359609OAI: oai:DiVA.org:uu-151481DiVA: diva2:410081
Available from: 2011-04-12 Created: 2011-04-12 Last updated: 2017-12-11Bibliographically approved

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