Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis
2008 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 34, no 5, 547-552 p.Article in journal (Refereed) Published
To investigate if the pattern of cytotoxic drug sensitivity in vitro in patient samples of peritoneal carcinomatosis (PC) is supportive to the current standardized approach for drug selection for perioperative intraperitoneal chemotherapy (IPC).
The cytotoxic effect of cisplatin, oxaliplatin, irinotecan, 5-fluorouracil, mitomycin-C, doxorubicin and melphalan was investigated in vitro on tumour cells from 223 patient tumour samples of different PC origins.
Considerable differences in cytotoxic drug sensitivity between tumour types of the PC entity and within each tumour type were observed. Cisplatin showed high cross-resistance with oxaliplatin but low cross-resistance with doxorubicin and irinotecan. No cross-resistance was found between irinotecan and doxorubicin. The dose-response relationships for melphalan and irinotecan in individual samples showed great variability.
The activity in vitro of cytotoxic drugs commonly used in IPC for PC is very heterogeneous. Efforts for individualizing drug selection for PC patients undergoing IPC seem justified.
Place, publisher, year, edition, pages
2008. Vol. 34, no 5, 547-552 p.
Peritoneal carcinomatosis, Intraperitoneal chemotherapy, Cytotoxic drug, In vitro
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-13245DOI: 10.1016/j.ejso.2007.05.002ISI: 000256207400012PubMedID: 17574369OAI: oai:DiVA.org:uu-13245DiVA: diva2:41015