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Monoallelic expression of MAO-A in skin fibroblasts
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2007 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 114, no 6, 713-716 p.Article in journal (Refereed) Published
Abstract [en]

X chromosome inactivation in mammalian females occurs early in embryonic development and renders most genes on the inactive X chromosome transcriptionally silenced. As a consequence, females will display an X chromosomal parent-of-origin mosaicism with regard to which parental allele that is expressed. Some genes however, escape inactivation and will therefore be expressed from both alleles. In this study we have investigated if the X-linked MAO-A gene have bi- or mono-allelic expression. This information would indicate whether or not MAO-A gene dosage could potentially explain the observed gender differences that show functional connections to the serotonin system, such as aggression and impulsiveness. To investigate the X inactivation status of MAO-A we have used primary clonal cell cultures, on which allelic expression was assessed with RFLP analysis. Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences.

Place, publisher, year, edition, pages
2007. Vol. 114, no 6, 713-716 p.
Keyword [en]
female, fibroblast, monoamine oxidase, gene, chromosome X, aggression, impulsiveness
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-151499DOI: 10.1007/s00702-007-0676-xISI: 000246735100006PubMedID: 17406964OAI: oai:DiVA.org:uu-151499DiVA: diva2:410224
Available from: 2011-04-13 Created: 2011-04-12 Last updated: 2017-12-11Bibliographically approved

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