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Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide
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2009 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, Vol. 50, no 7, 1198-1203 p.Article in journal (Refereed) Published
Abstract [en]

Celecoxib, an inhibitor of cyclooxygenase-2, is a promising novel antitumor agent with pleitropic mechanisms of action. Whereas this drug induces growth arrest and apoptosis of B-lymphoma cells, its effect against aggressive T-cell neoplasms remains to be studied. We therefore evaluated Celecoxib therapy of immunocompetent mice transplanted with lymphoblastic T-cell lymphomas. Oral Celecoxib in clinically relevant and non-toxic doses did not affect the degree of hypersplenism or the number of viable lymphoma cells. The clinical deterioration of Celecoxib-treated mice was not different from untreated controls. The impact of adding Celecoxib (60 mg/kg) to cyclophosphamide (200 mg/kg x 1, i.p.) was assessed but showed no benefit compared to cyclophosphamide alone. Thus, Celecoxib lacks effect against lymphoblastic T-cell lymphoma in mice.

Place, publisher, year, edition, pages
2009. Vol. 50, no 7, 1198-1203 p.
Keyword [en]
T-cell lymphoma, mouse, prostaglandins, Celecoxib, chemotherapy
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-151988DOI: 10.1080/10428190902946930ISI: 000267371600021PubMedID: 19557641OAI: oai:DiVA.org:uu-151988DiVA: diva2:411967
Available from: 2011-04-20 Created: 2011-04-20 Last updated: 2011-04-20Bibliographically approved

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