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Onlay and inlay bone grafts with platelet-rich plasma: histologic evaluations from human biopsies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery.
2011 (English)In: Journal of oral and maxillofacial surgery (Print), ISSN 0278-2391, E-ISSN 1531-5053, Vol. 69, no 4, 1079-1085 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to histomorphometrically evaluate biopsies from 1) sinus inlay bone grafts prepared with or without platelet-rich plasma (PRP) and 2) onlay bone grafts in the anterior maxilla with particulate bone and PRP or block bone without PRP after 3 months. Materials and Methods Biopsies were retrieved with a trephine drill, and samples were processed in laboratories to result in nondecalcified cut and ground sections. Light microscopic measurements of total bone area, new bone, number of vessels, and vessel area were performed at 3 regions in each sample. Calculations of ratios of new bone to total bone and vessel area to total area were performed. Results There was a tendency toward higher mean values for total bone area percentage and area of newly formed bone in the PRP-treated inlay biopsies. However, there was no measurable effect on vessel formation in the PRP-treated inlay samples compared with untreated inlay samples. Particulate and PRP-treated onlay bone biopsies showed higher mean values in all measured parameters compared with block bone samples; however, no differences were statistically significant. Conclusion PRP treatment may favor bone formation in grafted bone, and further research is needed to describe the outcome of PRP treatment and grafting techniques in the maxilla.

Place, publisher, year, edition, pages
2011. Vol. 69, no 4, 1079-1085 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-151995DOI: 10.1016/j.joms.2010.11.027ISI: 000289123800027PubMedID: 21440827OAI: oai:DiVA.org:uu-151995DiVA: diva2:411985
Available from: 2011-04-20 Created: 2011-04-20 Last updated: 2011-05-02Bibliographically approved

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