uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Differences in voluntary ethanol consumption in Wistar rats from five different suppliers
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behaviour)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behaviour)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. (Neuropharmacology, Addiction and Behaviour)
2011 (English)In: Alcohol, ISSN 0741-8329, E-ISSN 1873-6823, Vol. 45, no 6, 607-614 p.Article in journal (Refereed) Published
Abstract [en]

Understanding the mechanism of action of ethanol and the neurobiological substrates for alcohol use disorders is challenging. In search of this knowledge, it is imperative to use valid animal experimental models. The Wistar rat is one example of a commonly used strain that also exert foundation stock for several rat lines selectively bred for high and low voluntary ethanol intake. Different studies report varying ethanol intake in Wistar rats posing the question of whether this is because of the methodological differences or the rat strain. The purpose of this study was therefore to compare voluntary ethanol intake in Wistar rats from five different suppliers. Rats from B&K Universal, UK (BK); Charles River, Germany; Harlan Laboratories, IN (Hsd); Harlan Laboratories, The Netherlands (RccHan™); and Taconic, Denmark were exposed to a three-bottle free-choice paradigm with intermittent 24h access to 5 and 20% ethanol and water three times per week for 6 weeks. A general finding was that the RccHan™ rats differed significantly from the other groups. At the end of the experiment, the RccHan™ group had the highest median ethanol intake of 3.85g/kg/24h, whereas the BK rats had the lowest intake of 1.84g/kg/24h. The preference for ethanol was also different throughout the experiment. At the end of the experiment, the RccHan™ rats had the highest preference of approximately 80%, whereas the BK rats had the lowest preference around 25%. During the 6-week drinking period, only the Hsd rats increased their ethanol intake, as evidenced by a significant increase of 5% ethanol intake. Although all rats are of Wistar origin, they display profound differences in voluntary ethanol consumption depending on the supplier. The choice of Wistar can therefore have implications for the outcome and make comparisons between studies difficult. The present findings highlight the supplier as an important parameter to consider when planning and performing preclinical animal studies in the field of alcohol research.

Place, publisher, year, edition, pages
2011. Vol. 45, no 6, 607-614 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-152037DOI: 10.1016/j.alcohol.2010.11.005ISI: 000294581900009PubMedID: 21168301OAI: oai:DiVA.org:uu-152037DiVA: diva2:412199
Note

Shared last authorships between Roman and Nylander

Available from: 2011-04-21 Created: 2011-04-21 Last updated: 2017-12-11

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Palm, SaraRoman, ErikaNylander, Ingrid

Search in DiVA

By author/editor
Palm, SaraRoman, ErikaNylander, Ingrid
By organisation
Department of Pharmaceutical Biosciences
In the same journal
Alcohol
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 414 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf