uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Non-stem cell origin for oligodendroglioma
Show others and affiliations
2010 (English)In: Cancer Cell, ISSN 1535-6108, E-ISSN 1878-3686, Vol. 18, no 6, 669-682 p.Article in journal (Refereed) Published
Abstract [en]

Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.

Place, publisher, year, edition, pages
2010. Vol. 18, no 6, 669-682 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152045DOI: 10.1016/j.ccr.2010.10.033PubMedID: 21156288OAI: oai:DiVA.org:uu-152045DiVA: diva2:412272
Available from: 2011-04-26 Created: 2011-04-21 Last updated: 2012-06-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
Cancer Cell
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 182 hits
ReferencesLink to record
Permanent link

Direct link