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Expression and function of vinculin in neuroendocrine tumors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kjell Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kjell Öberg)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kjell Öberg)
2007 (English)In: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 28, no 4, 196-204 p.Article in journal (Refereed) Published
Abstract [en]

Transfection of chicken vinculin into highly malignant neuroendocrine tumor cells, vasostatin-transformed (vaso-transformed) Bon cells which expressed low levels of vinculin protein, reversed their malignant behavior and restored expression of tumor suppressor genes. Conversely, small interfering RNA (siRNA)-mediated knockout of vinculin resulted in fast cell growth and augmentation of colony formation in wild-type cells. Moreover, expression of a tight junction protein, claudin 4 (CLD4), was found to be associated with vinculin expression. In the vaso-transformed Bon cells, CLD4 expression was reduced, whereas a significantly increased CLD4 expression was observed in the cells with vinculin overexpression. Furthermore, vinculin knockout brought about CLD4 downregulation in wild-type cells. However, vinculin and CLD4 expression was inversely correlated in neuroendocrine tumors, respectively. Based on these findings, we hypothesize that vinculin plays a role in growth regulation of neuroendocrine tumors. Further studies are necessary to analyze the relationship between the course of the disease, and vinculin and CLD4 expression in large tumor samples.

Place, publisher, year, edition, pages
2007. Vol. 28, no 4, 196-204 p.
Keyword [en]
Claudin 4, Neuroendocrine tumor, siRNA, Tumor suppressor gene, Vasostatin, Vinculin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-13477DOI: 10.1159/000107415ISI: 000249008900002PubMedID: 17709988OAI: oai:DiVA.org:uu-13477DiVA: diva2:41247
Available from: 2008-01-23 Created: 2008-01-23 Last updated: 2017-12-11Bibliographically approved

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Liu, MinghuiÖberg, KjellZhou, Yinghua

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