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No benefit of treatment with cyclophosphamide and autologous blood stem cell transplantation in multifocal motor neuropathy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
2008 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 117, no 6, 432-434 p.Article in journal (Refereed) Published
Abstract [en]

Introduction - Patients with multifocal motor neuropathy (MMN) usually respond to intravenous immunoglobulin (IVIG), but because of the short-lasting effect the treatment must be given repeatedly. Remission after treatment with high-dose cyclophosphamide has recently been reported in one patient refractory to IVIG. Case report - Here we report on a patient who responded to IVIG, but temporarily deteriorated dramatically after treatment with high-dose cyclophosphamide and autologous blood stem cell transplantation. Today the situation is the same as before the treatment with cyclophosphamide and blood stem cell transplantation, i.e. IVIG is given every 4 weeks. Conclusion - Our patient did not benefit from the treatment with high-dose cyclophosphamide and autologous blood stem cell transplantation. The effect of treatment with high-dose cyclophosphamide in MMN seems to be difficult to predict and that should be paid attention to if this type of treatment is considered.

Place, publisher, year, edition, pages
2008. Vol. 117, no 6, 432-434 p.
Keyword [en]
multifocal motor neuropathy, MMN, treatment, cyclophosphamide, blood stem cell transplantation
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-152144DOI: 10.1111/j.1600-0404.2007.00970.xISI: 000255600700010OAI: oai:DiVA.org:uu-152144DiVA: diva2:412533
Available from: 2011-04-25 Created: 2011-04-25 Last updated: 2017-12-11Bibliographically approved

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Axelson, Hans W.

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