uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden: Relations with season, age, ethnic origin and psychiatric diagnosis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
2010 (English)In: Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, E-ISSN 1879-1220, Vol. 121, no 1-2, 467-470 p.Article in journal (Refereed) Published
Abstract [en]

In a chart review at a psychiatric out-patient department, latitude 59.3 degrees N, a sample of patients with tests of serum 25-hydroxy-vitamin D (25-OHD) and plasma intact parathyroid hormone (iPTH) was collected, together with demographic data and psychiatric diagnoses. During 19 months, 117 patients were included. Their median 25-0HD was 45 nmol/l; considerably lower than published reports on Swedish healthy populations. Only 14.5% had recommended levels (over 75). In 56.4%, 25-OHD was under 50 nmol/l, which is related to several unfavourable health outcomes. Seasonal variation of 25-OHD was blunted. Patients with ADHD had unexpectedly low iPTH levels. Middle East, South-East Asian or African ethnic origin, being a young male and having a diagnosis of autism spectrum disorder or schizophrenia predicted low 25-OHD levels. Hence, the diagnoses that have been hypothetically linked to developmental (prenatal) vitamin D deficiency, schizophrenia and autism, had the lowest 25-OHD levels in this adult sample, supporting the notion that vitamin D deficiency may not only be a predisposing developmental factor but also relate to the adult patients' psychiatric state. This is further supported by the considerable psychiatric improvement that coincided with vitamin D treatment in some of the patients whose deficiency was treated.

Place, publisher, year, edition, pages
2010. Vol. 121, no 1-2, 467-470 p.
Keyword [en]
Vitamin D, Calcidiol, Parathyroid hormone, Blood levels, Out-patients, Chart review, Autism, Schizophrenia, Bipolar disorder, Depressive disorder, ADHD, Ethnic groups, Immigrants
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152279DOI: 10.1016/j.jsbmb.2010.03.013ISI: 000280600200105PubMedID: 20214992OAI: oai:DiVA.org:uu-152279DiVA: diva2:413229
Available from: 2011-04-28 Created: 2011-04-28 Last updated: 2011-04-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Psychiatry, University Hospital
In the same journal
Journal of Steroid Biochemistry and Molecular Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 176 hits
ReferencesLink to record
Permanent link

Direct link