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Insulin-like growth factor-1 as an indicator of nutrition during treatment of adolescent girls with eating disorders
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. (Barnendokrinologisk forskning/Tuvemo)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Clinical Chemistry)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
2007 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 96, no 8, 1203-1208 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The use of serum insulin-like growth factor-1 (IGF-1) concentrations as an index of nutrition has been analysed in teenage girls with eating disorders and weight loss.

Method: Blood samples for analysis of IGF-1 were obtained at 349 assessments of 302 patients and biweekly during 56 treatment periods in 46 patients. IGF-1 was related to body size, weight loss, degree of leanness (BMI standard deviation score) and rate of weight loss.

Results: At assessment, when most of the girls were on a weight-losing course, serum IGF-1 concentrations were low. Weight loss immediately prior to assessment was the most important predictor of IGF-1. Together with measurements of weight, height, weight loss and BMI standard deviation score the rate of weight loss predicted IGF-1 to 32–55%. During treatment when there was net weight gain, IGF-1 increased in parallel with the BMI standard deviation score, a measure of leanness, and was also influenced by the short-term weight trend.

Conclusion: The serum IGF-1 concentration is an indicator of nutritional status in adolescents with eating disorders. It is sensitive to short-term weight changes measured in a clinical setting and could be used at assessment and to monitor nutritional rehabilitation.

Place, publisher, year, edition, pages
2007. Vol. 96, no 8, 1203-1208 p.
Keyword [en]
Anorexia nervosa, Eating disorder, Insulin-like growth factor-1, Nutrition
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-13557DOI: 10.1111/j.1651-2227.2007.00400.xISI: 000248282500022PubMedID: 17655621OAI: oai:DiVA.org:uu-13557DiVA: diva2:41327
Available from: 2008-03-25 Created: 2008-03-25 Last updated: 2017-12-11Bibliographically approved

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Swenne, Ingemar

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