Insulin-like growth factor-1 as an indicator of nutrition during treatment of adolescent girls with eating disorders
2007 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 96, no 8, 1203-1208 p.Article in journal (Refereed) Published
Aim: The use of serum insulin-like growth factor-1 (IGF-1) concentrations as an index of nutrition has been analysed in teenage girls with eating disorders and weight loss.
Method: Blood samples for analysis of IGF-1 were obtained at 349 assessments of 302 patients and biweekly during 56 treatment periods in 46 patients. IGF-1 was related to body size, weight loss, degree of leanness (BMI standard deviation score) and rate of weight loss.
Results: At assessment, when most of the girls were on a weight-losing course, serum IGF-1 concentrations were low. Weight loss immediately prior to assessment was the most important predictor of IGF-1. Together with measurements of weight, height, weight loss and BMI standard deviation score the rate of weight loss predicted IGF-1 to 32–55%. During treatment when there was net weight gain, IGF-1 increased in parallel with the BMI standard deviation score, a measure of leanness, and was also influenced by the short-term weight trend.
Conclusion: The serum IGF-1 concentration is an indicator of nutritional status in adolescents with eating disorders. It is sensitive to short-term weight changes measured in a clinical setting and could be used at assessment and to monitor nutritional rehabilitation.
Place, publisher, year, edition, pages
2007. Vol. 96, no 8, 1203-1208 p.
Anorexia nervosa, Eating disorder, Insulin-like growth factor-1, Nutrition
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-13557DOI: 10.1111/j.1651-2227.2007.00400.xISI: 000248282500022PubMedID: 17655621OAI: oai:DiVA.org:uu-13557DiVA: diva2:41327