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The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2008 (English)In: Histopathology, ISSN 0309-0167, E-ISSN 1365-2559, Vol. 53, no 1, 30-38 p.Article in journal (Refereed) Published
Abstract [en]

Aims: Macrophage colony-stimulating factor (M-CSF) binds to colony-stimulating factor-1 receptor (CSF-1R) and stimulates proliferation and differentiation of monocytes, macrophages and their bone marrow progenitors. M-CSF, CSF-1R, the macrophage marker CD68, and the pan T-lymphocyte marker CD3 are increased in many human cancers. Their prognostic importance in primary prostatic carcinoma has not been fully delineated. The aim was to compare the expression of M-CSF, CSF-1R, CD68 and CD3 in metastatic and non-metastatic prostatic cancer. Methods and results: Digital video analysis of tumour cell areas and tumour stromal areas was performed in 59 cancer specimens: 32 patients with metastases and 27 patients without metastases. Expression of M-CSF and CSF-1R was recorded as 0 (negative immunoreactivity), 1 (weak), 2 (moderate) or 3 (strong reactivity). Macrophages (CD68) and T lymphocytes (CD3) were detected as proportions of moderately or strongly immunoreactive cells. Patients with metastatic primary cancers showed higher expression of M-CSF (P < 0.0001, P = 0.005), CSF-1R (both P < 0.0001) and CD3 (P = 0.007, P < 0.0001) in both tumour cell areas and tumour stromal areas, compared with the non-metastatic cancers. Conclusions: This study suggests that expression of M-CSF, CSF-1R and CD3 is a significant prognostic factor in primary prostatic cancers by predicting the development of metastases.

Place, publisher, year, edition, pages
2008. Vol. 53, no 1, 30-38 p.
Keyword [en]
CD3, CD68, CSF-1 receptor, digital video analysis, M-CSF metastases, macrophages, prognosis, prostatic cancer, T lymphocytes
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152332DOI: 10.1111/j.1365-2559.2008.03058.xISI: 000256970400003PubMedID: 18510570OAI: oai:DiVA.org:uu-152332DiVA: diva2:413326
Available from: 2011-04-28 Created: 2011-04-28 Last updated: 2011-04-28Bibliographically approved

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