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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
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2011 (English)In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 43, no 4, 339-344 p.Article in journal (Refereed) Published
Abstract [en]

Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.

Place, publisher, year, edition, pages
2011. Vol. 43, no 4, 339-344 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-151963DOI: 10.1038/ng.782ISI: 000288903700014PubMedID: 21378988OAI: oai:DiVA.org:uu-151963DiVA: diva2:413660
Available from: 2011-04-29 Created: 2011-04-20 Last updated: 2017-12-11Bibliographically approved

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