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In search of the Holy Grail: Folate-targeted nanoparticles for cancer therapy
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
VTT Technical Research Center of Finland, Department of Medical Biotechnology, Turku, Finland.
Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm and Childhood Cancer Research Unit, Department of Women's and Children's Health, Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm.
2011 (English)In: Biochemical Pharmacology, ISSN 0006-2952, E-ISSN 1356-1839, Vol. 81, no 8, 976-984 p.Article in journal (Refereed) Published
Abstract [en]

Targeted drug therapy or "smart" drug delivery, potentially combined with simultaneous imaging modalities to monitor the delivery of drugs to specific tissues, is arguably the "holy grail" of pharmacology. Therapeutic approaches that exploit nanoparticles to deliver drugs selectively to cancer cells are currently considered one of the most promising avenues in the area of cancer therapeutics and imaging. The potential to deliver active chemotherapeutic drugs in the vicinity or directly within specific tumors via receptor mediated pathways, and to image tumors through the use of nanoparticles has been conceptually and experimentally shown for several classes of nanoparticles. Nanoparticles functionalized with the vitamin folic acid are of particular interest as a variety of malignant tumors are known to overexpress the folate receptor(s). Indeed, several nanoparticle architectures with improved retention time, administration route, biocompatibility, absorption, and clearance are being proposed and are in late stage clinical development. This commentary highlights some of the most important concepts related to nanoparticles and folate-mediated drug delivery and imaging in cancer research.

Place, publisher, year, edition, pages
2011. Vol. 81, no 8, 976-984 p.
Keyword [en]
Nanoparticle, Folic acid, Targeted delivery, Toxicity
National Category
Medical and Health Sciences Engineering and Technology
URN: urn:nbn:se:uu:diva-152660DOI: 10.1016/j.bcp.2011.01.023ISI: 000289036400002PubMedID: 21300030OAI: oai:DiVA.org:uu-152660DiVA: diva2:413780
Available from: 2011-04-29 Created: 2011-04-29 Last updated: 2014-12-16Bibliographically approved

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