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Hundratals genvarianter kopplade till hjärt-kärlsjukdom: Revolution inom populationsbaserad forskning - ännu inte inom kliniken
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
2011 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 108, no 1-2, 26-30 p.Article in journal (Refereed) Published
Abstract [en]

Genetic factors are important for the development of cardiovascular disease (CVD) and related conditions, and it is crucial to better understand the complex interactions between genetic and environmental factors contributing to these diseases. In the last 3-4 years, we have seen a remarkable development within population-based genetics, and through the genome-wide association studies (GWAS) we now know of hundreds of genetic variants robustly associated with CVD and related conditions. In the coming few years, we are facing a rapid development with exponentially increasing amounts of data from sequencing methods, but also from new techniques for analyzing mRNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics). As a result, we have to be prepared to adapt from a primarily hypothesis-driven and locally focused research philosophy towards a more hypothesis-generating and international, collaborative way of thinking about biomedical population-based research in general.

Place, publisher, year, edition, pages
2011. Vol. 108, no 1-2, 26-30 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152726PubMedID: 21365810OAI: oai:DiVA.org:uu-152726DiVA: diva2:413838
Available from: 2011-04-29 Created: 2011-04-29 Last updated: 2011-11-07Bibliographically approved

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