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Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Department of Nuclear Medicine)
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2011 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 52, no 2, 173-180 p.Article in journal (Refereed) Published
Abstract [en]

Background:

Diffusion-weighted imaging (DWI) has become increasingly valuable in lymph node imaging, yet the clinical utility of this technique in the staging of lymphoma has not been established.

Purpose:

To compare whole-body DWI with FDG-PET/CT in the staging of lymphoma patients.

Material and Methods:

Thirty-one patients, eight with Hodgkin lymphoma (HL) and 23 with non-Hodgkin's lymphoma (18 aggressive and five indolent) underwent both whole-body DWI, whole-body MRI (T1W and T2W-STIR) and FDG-PET/CT. Lesions on whole-body DWI were only considered positive if they correlated with lesions on T1W and T2W-STIR images. The staging given by each technique was compared, according to the Ann Arbor staging system. Differences in staging were solved using biopsy results, and clinical and CT follow-ups as standard of reference.

Results:

The staging was the same for DWI and FDG-PET/CT in 28 (90.3%) patients and different in three (9.7%). Of the 28 patients with the same staging, 11 had stage IV in both techniques and 17 had stages 0-III. No HL or aggressive non-Hodgkin's lymphoma patients had different staging. Three indolent small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) lymphoma had higher staging with DWI when compared with FDG-PET/CT. One small subcutaneous breast lymphoma was not seen but all other extranodal sites were detected by both techniques.

Conclusion:

Whole-body DWI is a promising technique for staging of both (aggressive and indolent) non-Hodgkin's lymphoma and HL.

Place, publisher, year, edition, pages
2011. Vol. 52, no 2, 173-180 p.
Keyword [en]
Whole-body diffusion-weighted imaging, lymphoma, FDG-PET/CT
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-152737DOI: 10.1258/ar.2010.100246ISI: 000290498900009PubMedID: 21498346OAI: oai:DiVA.org:uu-152737DiVA: diva2:413900
Available from: 2011-04-29 Created: 2011-04-29 Last updated: 2017-12-11Bibliographically approved

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Abdul Qadhr, GöranMolin, DanielÅström, GunnarJohansson, LarsHagberg, HansAhlström, Håkan

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