Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients
2011 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 52, no 2, 173-180 p.Article in journal (Refereed) Published
Diffusion-weighted imaging (DWI) has become increasingly valuable in lymph node imaging, yet the clinical utility of this technique in the staging of lymphoma has not been established.
To compare whole-body DWI with FDG-PET/CT in the staging of lymphoma patients.
Material and Methods:
Thirty-one patients, eight with Hodgkin lymphoma (HL) and 23 with non-Hodgkin's lymphoma (18 aggressive and five indolent) underwent both whole-body DWI, whole-body MRI (T1W and T2W-STIR) and FDG-PET/CT. Lesions on whole-body DWI were only considered positive if they correlated with lesions on T1W and T2W-STIR images. The staging given by each technique was compared, according to the Ann Arbor staging system. Differences in staging were solved using biopsy results, and clinical and CT follow-ups as standard of reference.
The staging was the same for DWI and FDG-PET/CT in 28 (90.3%) patients and different in three (9.7%). Of the 28 patients with the same staging, 11 had stage IV in both techniques and 17 had stages 0-III. No HL or aggressive non-Hodgkin's lymphoma patients had different staging. Three indolent small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) lymphoma had higher staging with DWI when compared with FDG-PET/CT. One small subcutaneous breast lymphoma was not seen but all other extranodal sites were detected by both techniques.
Whole-body DWI is a promising technique for staging of both (aggressive and indolent) non-Hodgkin's lymphoma and HL.
Place, publisher, year, edition, pages
2011. Vol. 52, no 2, 173-180 p.
Whole-body diffusion-weighted imaging, lymphoma, FDG-PET/CT
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-152737DOI: 10.1258/ar.2010.100246ISI: 000290498900009PubMedID: 21498346OAI: oai:DiVA.org:uu-152737DiVA: diva2:413900