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Essential fatty acid status in teenage girls with eating disorders and weight loss
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Child and Adolescent Psychiatry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
2011 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 100, no 5, 762-767 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To explore the relationship between essential fatty acids (FA) and weight changes in adolescent girls with eating disorders (ED). Methods: Blood samples were obtained from 220 girls with ED and 39 healthy controls. The girls with ED were 15.3 +/- 1.5 years of age and weighed 49.8 +/- 8.7 kg (BMI 18.3 +/- 2.8 kg/m2) after a weight loss of 6.8 +/- 6.4 kg. FA were analysed in plasma phospholipids (PPL) and erythrocyte membranes (ERY). Results: The proportions of saturated and monounsaturated FA were increased during weight loss, while linoleic acid (18:2 omega 6) was decreased. The proportions of eicosapentanoic acid (EPA) (20:5 omega 3) and docosahexanoic acid (DHA) (22:6 omega 3) in PPL and ERY did not differ from controls. The activity of stearoyl-CoA-desaturase was increased as evidenced by an increased product/precursor ratio and correlated with the rate of weight loss. The activities of delta-6-desaturase and delta-5-desaturase did not differ from controls. The rate of weight loss was inversely correlated with delta-6-desaturase and directly correlated with delta-5-desaturase. Conclusion: The FA profile indicates low-fat intake, fat mobilization from stores and an increased conversion of essential FA at the delta-5-desaturase step during weight loss in adolescent girls with ED. Normal levels of EPA and DHA were maintained.

Place, publisher, year, edition, pages
2011. Vol. 100, no 5, 762-767 p.
Keyword [en]
Delta-5-desaturase, Delta-6-desaturase, Eating disorder, Essential fatty acids, Stearoyl-CoA-desaturase
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-152866DOI: 10.1111/j.1651-2227.2011.02153.xISI: 000289250200028PubMedID: 21362034OAI: oai:DiVA.org:uu-152866DiVA: diva2:414159
Available from: 2011-05-02 Created: 2011-05-02 Last updated: 2017-12-11Bibliographically approved

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