76Br-labeled monoclonal anti-CEA antibodies for radioimmuno positron emission tomography
1995 (English)In: Nuclear Medicine and Biology, ISSN 0969-8051, E-ISSN 1872-9614, Vol. 22, no 1, 125-131 p.Article in journal (Refereed) Published
For the application of anti-tumor monoclonal antibodies (MAbs) in positron emission tomography (PET), labeling radionuclides with half-lives allowing a suitable time frame for imaging are required. The anti-CEA MAb 38S1 was labeled with the positron emitting nuclide 76Br (t1/2 16 h) using bromoperoxidase (BPO), and subsequently affinity purified. A procedure was devised to allow reproducible production of MAb-preparations of high immunoreactivity and with acceptable bromination yield. The biological activity of 76Br-38S1 was retained and comparable to that of chloramine-T labeled 125I-38S1, as tested in vitro.
Place, publisher, year, edition, pages
1995. Vol. 22, no 1, 125-131 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-152882DOI: 10.1016/0969-8051(94)E0065-QPubMedID: 7735162OAI: oai:DiVA.org:uu-152882DiVA: diva2:414235