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Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [C-11]vorozole
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2011 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 22, no 7, 326-330 p.Article in journal (Refereed) Published
Abstract [en]

In an earlier study in rodents, we showed that the aromatase that converts androgens to estrogens in the preoptic area and bed nucleus of stria terminalis was significantly increased in concentration after exposure to anabolic-androgenic steroids. To confirm whether this occurs in primates, we conducted a positron emission tomographic study using macaque monkeys. Male rhesus monkeys were treated with nandrolone decanoate for 3 weeks. To measure aromatase concentrations, we performed positron emission tomographic imaging using a C-11-labeled specific aromatase inhibitor, [C-11] vorozole. After treatment with nandrolone, significant increase in [C-11] vorozole binding was observed in the hypothalamus but not other areas including the amygdala, which is also aromatase enriched. These findings in monkeys are consistent with those we obtained earlier in rats. These findings strongly suggest that aromatase in the hypothalamus may play a crucial role in the emotional instability of anabolic-androgenic steroids abusers. NeuroReport 22:326-330 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Place, publisher, year, edition, pages
2011. Vol. 22, no 7, 326-330 p.
Keyword [en]
anabolic-androgenic steroids, aromatase, hypothalamus, monkey, positron emission tomography
National Category
Natural Sciences Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152829DOI: 10.1097/WNR.0b013e3283460282ISI: 000289509900003OAI: oai:DiVA.org:uu-152829DiVA: diva2:414304
Available from: 2011-05-03 Created: 2011-05-02 Last updated: 2013-03-01Bibliographically approved

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Section of Nuclear Medicine and PETDepartment of Biochemistry and Organic Chemistry
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