uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Diagnostic properties of metabolic perturbations in rheumatoid arthritis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
Show others and affiliations
2011 (English)In: Arthritis Research and Therapy, ISSN 1478-6354, Vol. 13, no 1, R19- p.Article in journal (Refereed) Published
Abstract [en]

Introduction: The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. Methods: We compared the metabolic profile of patients with RA with that of healthy controls and patients with psoriatic arthritis (PsoA). The metabolites were measured using two different chromatography-mass spectrometry platforms, thereby giving a broad overview of serum metabolites. The metabolic profiles of patient and control groups were compared using multivariate statistical analysis. The findings were validated in a follow-up study of RA patients and healthy volunteers. Results: RA patients were diagnosed with a sensitivity of 93% and a specificity of 70% in a validation study using detection of 52 metabolites. Patients with RA or PsoA could be distinguished with a sensitivity of 90% and a specificity of 94%. Glyceric acid, D-ribofuranose and hypoxanthine were increased in RA patients, whereas histidine, threonic acid, methionine, cholesterol, asparagine and threonine were all decreased compared with healthy controls. Conclusions: Metabolite profiling (metabolomics) is a potentially useful technique for diagnosing RA. The predictive value was without regard to the presence of antibodies against cyclic citrullinated peptides.

Place, publisher, year, edition, pages
2011. Vol. 13, no 1, R19- p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152926DOI: 10.1186/ar3243ISI: 000289523500030PubMedID: 21303541OAI: oai:DiVA.org:uu-152926DiVA: diva2:414396
Available from: 2011-05-03 Created: 2011-05-03 Last updated: 2011-05-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Organic Pharmaceutical Chemistry
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 162 hits
ReferencesLink to record
Permanent link

Direct link